Zymogen granule fraction Calf

Found In:

15817987

Description

Title: Zymogen granule fraction Calf
Creator: Green, L
Palade, George E
Published / Created: 2/2/1967
Publication Place: New Haven, CT
Publisher: Yale University School of Medicine
Description: 3.25 in. x 4 in. Lantern Slides
Original Magnification: x2,000
This study demonstrated directly that the enzyme and proenzyme composition of proteins in pancreatic juice collected from an indwelling catheter in the bovine pancreatic duct correlated exactly with the protein composition obtained from lysed purified bovine zymogen granules. Subsequent studies showed that pancreatic digestive enzymes and proenzymes were secreted from the pancreas in parallel. In other words, each granule must contain, on average, the same composition of secretory proteins. This hypothesis was later directly tested by immuno-EM localization of trypsinogen and other secretory proteins in all zymogen granules in the bovine pancreas.
Extent: 3.25 in. x 4 in.

Access: Public
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Yale Community Only
Citation: See Greene, L. J., C.H. Hirs, and G.E. Palade. 1963. On the protein composition of bovine pancreatic zymogen granules. J. Biol. Chem. 238:2054-2070.